Clostridioides difficile forms a spore that survives almost everything you’re using to disinfect a room. Standard hospital-grade disinfectant, the quaternary ammonium product most departments use every day, was never designed to kill it. Spores don’t have the metabolic machinery those chemistries attack. You can wipe a rail until it shines and the spore is still there, waiting for the next patient’s hands.
Sodium hypochlorite (Clorox Healthcare Bleach Germicidal Wipes) and peracetic acid-based products make up the overwhelming majority of EPA List K, the actual registered list of products with a kill claim against C. diff spores. Here’s the detail some training materials get wrong: the accelerated hydrogen peroxide products a lot of departments already stock for daily disinfection, the Oxivir and Accel lines, do carry a genuine C. diff sporicidal claim in Canada under Health Canada registration. They do not carry that claim here. If your daily disinfectant isn’t actually on EPA List K in the United States, it isn’t touching the spore, no matter how hospital-grade the label says it is.